In most cases using a No-CD or Fixed EXE will solve this problem!
ASSASSINS CREED 2 MODS MOD
This mod will allow you to improve picture quality with better color palette and some shader effects: Enb 0.076 Generic + SweetFX Shader Suite by CeeJay.dk and Crosire Version 2.0 and Marty McFly's Master Effects 1.4 Enb series mod include: - Noise Grain. I want to share with you configured Enb series mod for Assassin's Creed II.